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Alkaline Phosphatase Activity Induction in Human Spleen Sinuses in Storage Diseases.
Metadata
JournalVirchows Arch., B, Cell Pathol.Not FoundDate
1979-Dec
Type
Journal Article
Volume
1979-Dec / 32 : 89-92
Author
Elleder M
DoiPMIDMESH
Enzyme Induction
Gangliosidoses
Humans
Lysosomes
Mucopolysaccharidoses
Mucopolysaccharidosis I
Mucopolysaccharidosis II
Mucopolysaccharidosis III
Niemann-Pick Diseases
Spleen
Abstract
Human splenic sinuses were observed for the induction of alkaline phosphatase (AP) activity in mucopolysaccharidoses of type I and II, in GM1 gangliosidosis, and in Niemann-Pick's disease, type A. A substantially lower degree of activity was found in Sanfillipo's disease, type A, and in hemosiderin pigmentation of the sinuses. In a number of hematological affections and in control spleens AP activity could not be proved by histochemical means. From the formal pathogenetic view, enzyme activity induction is probably related to lysosomal deposition of the material stored.
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Virchows Arch., B, Cell Pathol.Virchows Archiv. B, Cell pathology including molecular pathology
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