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Metachromatic leukodystrophy and age: a comparative study of clinical, enzymological and ultrastructural findings.
Metadata
Journalclinical neurology and neurosurgery1.53Date
1979
Type
Journal Article
Comparative Study
Case Report
Volume
1979 / 81 : 221-33
Author
Luijten JA , Staal GE , Willemse J
DoiPMIDMESH
Adolescent
Adult
Age Factors
Alcoholism
Cerebroside-Sulfatase
Child
Female
Humans
Leukodystrophy, Metachromatic
Male
Peripheral Nerves
Psychotic Disorders
Syndrome
Abstract
The clinical findings of three cases of metachromatic leukodystrophy, one of the late infantile, one of the juvenile and one of the adult variant are described and compared with those mentioned in relevant publications. Comparison of our findings lead us to conclude that a difference exists between the late infantile case on the one hand and the juvenile and the adult case on the other hand. This conclusion concurs with the results obtained by the enzymological study of the enzyme arylsulfatase A derived from the three cases. As to the characteristics of the enzyme arylsulfatase A, a difference was found to exist between the enzyme of the late infantile case on the one hand and that of the juvenile and the adult case on the other hand. The results of the electronmicroscopic investigation of peripheral nerve biopsy specimens of the three cases are briefly summarized. It is postulated that the ultrastructural findings do not justify any such distinction.
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Clin Neurol Neurosurgclinical neurology and neurosurgery
Metadata
LocationNetherlands
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