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[Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results].
Metadata
JournalRev Inst Hyg Mines (Hasselt)Not FoundDate
1979
Type
Research Support, Non-U.S. Gov't
RCT
Journal Article
Comparative Study
Trial
Volume
1979 / 34 : 141-9
Author
Marcq M , Gepts L , Erven W , Minette A
Doi
Not Found
PMIDMESH
Aged
Almitrine
Carbon Dioxide
Central Nervous System Stimulants
Chronic Disease
Doxapram
Humans
Hypercapnia
Hypoxia
Middle Aged
Oxygen
Piperazines
Respiratory Insufficiency
Triazines
Abstract
We compared the effects of almitrine and doxapram on the arterial blood gases and ventilation of patients with chronic respiratory insufficiency and chronic hypercapnia and hypoxemia. Sixteen long-term in-patients were randomly allocated to one of the following treatment groups: the first group (8 patients) received IV almitrine 0.5 mg/kg and the second group (8 patients) IV doxapram 1 mg/kg by IV perfusion during 30 min. All gave their informed consent. Arterial blood gases and ventilation were measured 10 min and 5 min before treatment, at the 5th, 15th and 25th min of perfusion time, and 5, 10 and 15 min after infusion. There was a marked increase in paO2 in almitrine-treated patients, which was maximum at the 25th min of infusion (+ 14.6 mm Hg, p < 0.001), but only a slight improvement was observed in the doxapram group (+ 3.3 mm Hg, p < 0.05). After almitrine the maximum mean paCO2 decrease was at the 10th min after perfusion (-6.9 mm Hg, p < 0.001); after doxapram the maximum decrease, although highly significant, was much less (-2.8 mm Hg, p < 0.01). Thus, at the presently used and well-tolerated doses, almitrine is much more efficient than doxapram in improving gas exchange in patients with chronic hypoxemia and hypercapnia. However, complementary studies using higher dosage of doxapram are warranted.
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Rev Inst Hyg Mines (Hasselt)Revue de l'Institut d'hygiene des mines
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