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[Transplacental passage of cells from mother to fetus: experimental approach and initial results in the rat].
Metadata
JournalBull Assoc Anat (Nancy)Not FoundDate
1979-Dec
Type
Journal Article
English Abstract
Volume
1979-Dec / 63 : 397-410
Author
Gérard H , Kohler F
Doi
Not Found
PMIDMESH
Animals
Female
Fetus
Graft vs Host Reaction
Maternal-Fetal Exchange
Pregnancy
Rats
Abstract
The consequences of transfusion across the placenta of maternal cells to fetuses, supposed to elicit a Graft-Versus-Host-Reaction, are poorly investigated; the injection of pregnant rat whole blood cells to its own fetuses is proposed here as a convenient experimental model to improve the understanding of these consequences; indeed this technic is reliable as well as easy enough to carry out experiments on large samples. Preliminary results indicate that the injection is often followed by a runting disease, a thymic atrophy and a liver hypertrophy; splenomegaly does not occur. On the histologic level, the main features are as follows 1) modification of central lymphoïd organs, 2) blastic and/or granulocytic infiltrates of several other organs, namely the liver, the adrenal cortex and the thyroïd gland.
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Bull Assoc Anat (Nancy)Bulletin de l'Association des anatomistes
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