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Synthesis and pharmacological activity of derivatives of exo-trimethylenenorbornane. I.
Metadata
JournalFarmaco SciNot FoundDate
1979-Nov
Type
Journal Article
Volume
1979-Nov / 34 : 945-51
Author
Bondavalli F , Lanteri S , Longobardi M , Schenone P
Doi
Not Found
PMIDMESH
Amphetamine
Analgesics
Animals
Anti-Inflammatory Agents
Anticonvulsants
Antipsychotic Agents
Behavior, Animal
Camphanes
Chemical Phenomena
Chemistry
Male
Mice
Passive Cutaneous Anaphylaxis
Rats
Reserpine
Abstract
Lithium aluminum hydride reduction of exo-5,6-trimethylenenorbornan-2-one oxime gave in good yield exo-5,6-trimethylenenorbornan-2-endo-amine, from which a number of amides were prepared by reaction with acyl chlorides. Lithium aluminum hydride reduction of the above-mentioned amides afforded N-substituted exo-5,6-trimethylenenorbornan-2-endo-amines in good yields. Some amides showed CNS depressant and anti convulsant activity, and an amine convulsant activity in mice.
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Farmaco SciIl Farmaco; edizione scientifica
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