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Aminomethyl derivatives of 1-cyclohexyl-5-alkyl- and 1-cyclohexyl-5,5-dialkylbarbituric acids as potential antiinflammatory agents.
Metadata
JournalFarmaco SciNot FoundDate
1979-Nov
Type
Journal Article
Volume
1979-Nov / 34 : 979-86
Author
Sladowska H
Doi
Not Found
PMIDMESH
Animals
Anti-Inflammatory Agents
Barbiturates
Chemical Phenomena
Chemistry
Rats
Abstract
The synthesis and the structure of some aminomethyl derivatives of 1-cyclohexylbarbituric acids, obtained by the Mannich reaction, are described. Acids, containing a pyrrolidinomethyl group in the position 5 were found to have the barbituric ring in the enolic form, stabilized by a hydrogen bond with the pyrrolidine nitrogen atom. Some of the described compounds displayed antiinflammatory activity.
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Farmaco SciIl Farmaco; edizione scientifica
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