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Therapeutic efficiency of spleen or bone marrow CFU in X-irradiated 89Sr marrow-ablated mice.
Metadata
JournalInt. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.Not FoundDate
1979-Dec
Type
Journal Article
Volume
1979-Dec / 36 : 595-600
Author
Duplan JF , Legrand E , Castaignos C , de Calignon E
DoiPMIDMESH
Animals
Bone Marrow
Bone Marrow Cells
Colony-Forming Units Assay
Female
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Kinetics
Male
Mice
Spleen
Splenectomy
Time Factors
X-Rays
Abstract
Experiments were carried out to compare the therapeutic efficiency (TE: number of CFU required to reduce the mortality from 100 to 50 per cent) of spleen or marrow (BM) stem cells (CFU) grafted into lethally irradiated mice (807 rad) which had been previously treated with 89Sr or splenectomized. It was found that during the reconstitution of the haemopoietic organs, the spleen does not provide more than 10 per cent of the functional cells necessary for survival. Besides, the BM-derived CFU growing in 89Sr marrow-ablated mice remain twice as efficient as the spleen-derived ones. Similarly, spleen-derived CFU transplanted into splenectomized mice are half as efficient as BM-derived ones. It may therefore be assumed that haemopoietic stem cells grafted into a foreign microenvironment retain their original kinetics of growth and differentiation during 7 to 10 days after their transplantation.
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Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.International journal of radiation biology and related studies in physics, chemistry, and medicine
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