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Activation of phosphatidylserine synthesis: a possible mechanism of regulation of the base-exchange enzymic system.
Metadata
JournalItal. J. Biochem.Not FoundDate
1979-Nov-Dec
Type
Journal Article
Volume
1979-Nov-Dec / 28 : 423-32
Author
Castigli E , Mezzasoma I , Di Donato A , Porcellati G
Doi
Not Found
PMIDMESH
3',5'-Cyclic-AMP Phosphodiesterases
Animals
Caudate Nucleus
Cyclic AMP
Dopamine
Female
Hydrogen-Ion Concentration
Imidazoles
In Vitro Techniques
Male
Phosphatidylserines
Rats
Serine
Abstract
The possible relationship between phosphatidyl serine synthesis by base-exchange and nervous activity has been investigated in the rat caudate nucleus. The rate of incorporation of L-serine into the phosphatidyl serine of slices from caudate nucleus is not affected by dopamine nor is it affected by the addition to dopamine of a cyclic phosphodiesterase inhibitor which would increase the endogenous cyclic-AMP levels. However, imidazole, a phosphodiesterase activator, clearly stimulates by more than 100% the phosphatidyl serine synthesis in the slices. The activation is not due to interaction at the catalytic site(s) of the base-exchange system, since it is neither observed in homogenates of caudate nucleus nor in cerebral microsomes at various pH values.
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Ital. J. Biochem.The Italian journal of biochemistry
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