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Effect of beta-blocking agents in hyperthyroidism.
Metadata
JournalActa Med Acad Sci HungNot FoundDate
1979
Type
Journal Article
Volume
1979 / 36 : 375-80
Author
Földes J , Bános C , Borvendég J , Gyertyánfy G
Doi
Not Found
PMIDMESH
Adrenergic beta-Antagonists
Adult
Cyclic AMP
Female
Heart Rate
Humans
Hyperthyroidism
Middle Aged
Propanolamines
Propranolol
Thyroxine
Triiodothyronine
Abstract
Propranolol modifies peripheral thyroxine metabolism, in opposition to the beta blocking agent GYKI 41099 which has no such effect. Both beta-receptor blockers produce a significant fall in the serum cAMP level of hyperthyroid subjects. It is suggested that the beneficial effect of the beta-blocking agents in hyperthyroidism is partly due to their depressive effect on cAMP production. As far as the action of propranolol is concerned, it may well involve an additional effect on T4 metabolism.
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Acta Med Acad Sci HungActa medica Academiae Scientiarum Hungaricae
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