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[Sympathetic mediation of induced and spontaneous activity of the pelvis-ureter in vitro].
Metadata
JournalBoll. Soc. Ital. Biol. Sper.Not FoundDate
1979-Apr-30
Type
Journal Article
English Abstract
Volume
1979-Apr-30 / 55 : 740-5
Author
Mitolo-Chieppa D , Cagnazzo F
Doi
Not Found
PMIDMESH
Adrenergic alpha-Antagonists
Angiotensin II
Animals
Barium
Barium Compounds
Chlorides
Dihydroergotamine
Electric Stimulation
Guinea Pigs
Histamine
In Vitro Techniques
Kidney Pelvis
Muscle Contraction
Norepinephrine
Phentolamine
Ureter
Abstract
The spontaneous activity of guinea-pig renal pelvis-ureter is regulated by the adrenergic system. Spontaneous rhythmic contractions, and contractions induced by Noradrenaline are inhibited by Dihidroergotamine and Phentolamine. Alpha-adrenergic blocking agents block also contractions induced by histamine, angiotensin and barium chloride, but not contractions induced by electric stimulation. The Authors suggest an hypothetical model for the activation of the adrenergic receptor: Noradrenaline (NE) recognition sites are activated only by NE, whereas complementary sites can be activated by NE or other agonists. Both sites are blocked by alpha-adrenergic blocking agents.
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Boll. Soc. Ital. Biol. Sper.Bollettino della Societa italiana di biologia sperimentale
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