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Antagonistic properties of N-methyl-N'-[2-(5-ethyl-4-imidazolyl-methylthio)ethyl]thiourea.
Metadata
JournalFarmaco SciNot FoundDate
1979-May
Type
Journal Article
Volume
1979-May / 34 : 403-8
Author
Vitali T , Ferrari C , Bertaccini G , Impicciatore M
Doi
Not Found
PMIDMESH
Animals
Cats
Female
Guinea Pigs
Histamine H2 Antagonists
Imidazoles
In Vitro Techniques
Rats
Abstract
In the present paper the Authors describe the synthesis and the biological effects of N-methyl-N'-[2-(5-ethyl-4-imidazolylmethylthio)ethyl]thiourea (etiamide). This compound appeared to inhibit, to a certain extent, the effect of histamine on H2-receptors. This inhibition, however, was less pronounced than that elicited by metiamide and in some of the preparations examined appeared to be of the non-competitive type.
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Farmaco SciIl Farmaco; edizione scientifica
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