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Oxidant-induced alterations in pulmonary microsomal mixed-function oxidation: acute effects of paraquat and ozone.
Metadata
JournalJ Environ Sci Health CNot FoundDate
1979
Type
Research Support, U.S. Gov't, P.H.S.
Journal Article
Comparative Study
Volume
1979 / 13 : 205-19
Author
Montgomery MR , Niewoehner DE
Doi
Not Found
PMIDMESH
Animals
Cytochrome P-450 Enzyme System
Cytochromes
Cytochromes b5
Dose-Response Relationship, Drug
In Vitro Techniques
Kinetics
Lung
Male
Microsomes
Mixed Function Oxygenases
Oxidoreductases
Oxidoreductases, N-Demethylating
Ozone
Paraquat
Rats
Stearoyl-CoA Desaturase
Abstract
Pulmonary mixed function oxidations are altered by in vivo exposure to paraquat or ozone. The cytochrome P-450-mediated benzphetamine N-demethylase activity was inhibited by low doses of both oxidants (paraquat, 20 mg/kg, ip; ozone, 1 ppm, 24 hrs). The effect of paraquat did not appear until 4 days after treatment and was still apparent after 2 weeks. The inhibition following exposure to ozone appeared immediately (1 day) and had resolved by one week. Cytochrome b5-mediated lipid desaturation was unaffected by the paraquat treatment and was stimulated by ozone. These alterations in pulmonary mixed function oxidase activities could not be explained by microsomal lipid peroxidation. The concentrations of cytochromes P450 and b5 also did not accurately reflect the altered enzymatic activities. The sites of the paraquat- and ozone-mediated alterations are still unknown.
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J Environ Sci Health CJournal of environmental science and health. Part C: Environmental health sciences
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