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Extracellular pH selectively modulates recovery from sodium inactivation in frog myelinated nerve.
Metadata
Journalbiophysical journal3.854Date
1979-Nov
Type
Research Support, U.S. Gov't, P.H.S.
Journal Article
Volume
1979-Nov / 28 : 363-8
Author
Courtney KR
DoiPMIDMESH
Animals
Hydrogen-Ion Concentration
Kinetics
Models, Biological
Myelin Sheath
Rana catesbeiana
Sciatic Nerve
Sodium
Abstract
The Hodgkin-Huxley kinetic parameters, alpha h and beta h, which govern the rate of recovery from and development of sodium channel inactivation, respectively, have been measured as a function of membrane potential and external pH using a three-pulse protocol. alpha h but not beta h is substantially accelerated by reducing external pH from 7.4 to 6.4. The alpha h vs. voltage curve appears to be selectively shifted in the depolarizing direction by approximately 12 mV for this pH change, giving an apparent, h infinity curve shift of approximately 6 mV in the same direction (less inactivation).
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3.9
Biophys Jbiophysical journal
Metadata
LocationUnited States
FromCELL PRESS

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