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5,7-dihydroxytryptamine lesions of dorsal and median raphé nuclei and performance in the social interaction test of anxiety and in a home-cage aggression test.
Metadata
Journaljournal of affective disorders3.892Date
1979-Jun
Type
Journal Article
Volume
1979-Jun / 1 : 115-22
Author
File SE , Hyde JR , MacLeod NK
DoiPMIDMESH
5,7-Dihydroxytryptamine
Adrenocorticotropic Hormone
Aggression
Animals
Anti-Anxiety Agents
Anxiety
Benzodiazepines
Brain Mapping
Brain Stem
Humans
Male
Raphe Nuclei
Rats
Serotonin
Social Behavior
Abstract
Micro-injections of the neurotoxin 5,7-dihydroxytryptamine into the dorsal raphe nucleus produced a behavioural profile in the social interaction test of anxiety similar to that seen in rats treated chronically with benzodiazepines. Neurotoxin injections into the median raphé nucleus did not produce a profile significantly different from that of the controls. In the control rats and in the rats with lesions of the median raphé nucleus, ACTH1-24 (corticotrophin) significantly reduced active social interactions, whereas it was without effect on the rats with lesions of the dorsal raphé nucleus. In the home-cage intruder test, the median raphé-lesioned rats submitted less to the intruder and stood and jumped on him more often than did the controls. The dorsal raphé-lesioned rats showed significantly fewer interactions of all kinds, compared with control rats when an intruder was placed in their home cages.
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3.9
J Affect Disordjournal of affective disorders
Metadata
LocationNetherlands
FromELSEVIER

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