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Prospects for accelerating hematopoietic recovery following myelosuppressive therapy by using autologous, cryopreserved hematopoietic stem cells collected solely from the peripheral blood.
Metadata
Journalexperimental hematology2.82Date
1979
Type
Journal Article
Volume
1979 / 7 Suppl 5 : 107-15
Author
Abrams RA , Deisseroth AB
Doi
Not Found
PMIDMESH
Blood Preservation
Cell Separation
Freezing
Hematopoietic Stem Cell Transplantation
Monocytes
Abstract
Cryopreserved, autologous stem cells collected from human marrow have been used to accelerate hematopoietic recovery following intensive radiation or chemotherapy. The harvesting of adequate numbers of bone marrow cells for purposes of hematopoietic reconstitution is a potentially morbid procedure and requires the use of general anesthesia and blood transfusion during anesthesia. The ability to accelerate hematopoietic recovery using cells collected solely from the peripheral blood would obviate the requirement for a general anesthetic and avoid the discomfort experienced by patients following the procedure. Collection of hematopoietic stem cells from the peripheral blood should involve limited morbidity and risk and be well suited to repeated application in individual cases. An increasing body of in vitro and in vivo data in animals and man suggests that this goal may soon be within reach.
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2.8
Exp Hematolexperimental hematology
Metadata
LocationNetherlands
FromELSEVIER SCIENCE INC

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