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In vitro effect of dopamine and pimozide on human chorionic somatomammotropin (hCS) secretion.
Metadata
Journaljournal of clinical endocrinology & metabolism5.399Date
1978-Jul
Type
Research Support, U.S. Gov't, P.H.S.
Journal Article
Volume
1978-Jul / 47 : 168-70
Author
Macaron C , Famuyiwa O , Singh SP
DoiPMIDMESH
Arginine
Dopamine
Female
Glucose
Humans
Kinetics
Organ Culture Techniques
Pimozide
Placenta
Placental Lactogen
Pregnancy
Somatostatin
Abstract
In human placental explants cultured in vitro, dopamine inhibited human chorionic somatomammotropin (hCS) secretion into the culture media. In the control flasks, the level of hCS secretion was 130.5 +/- 7.8 micrograms/g tissue (n = 6). When 1 mM dopamine was added, hCS levels decreased to 80.2 +/- 11.5 micrograms/g tissue (P less than 0.01). Dopamine (5 and 10 mM) further lowered hCS levels. In contrast, 1 mM pimozide enhanced hCS secretion by 2-fold as compared to control levels (248.2 +/- 44.8 vs. 130.5 +/- 7.8, P less than 0.02). The simultaneous addition of dopamine did not alter the stimulatory effect of pimozide on hCS secretion. In separate experiments, arginine (1 and 5 mM) and somatostatin (1 microgram/ml culture media) did not alter hCS secretion from placental explants. These results suggest that hCS secretion is modulated by dopaminergic receptors.
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5.4
J Clin Endocrinol Metabjournal of clinical endocrinology & metabolism
Metadata
LocationUnited States
FromENDOCRINE SOC

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