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Failure of alpha-methyltyrosine to inhibit peripheral triiodothyronine formation.
Metadata
Journaljournal of clinical endocrinology & metabolism5.399Date
1978-Aug
Type
Research Support, U.S. Gov't, P.H.S.
Journal Article
Volume
1978-Aug / 47 : 442-4
Author
Dvorak JC , Engelman K , Utiger RD
DoiPMIDMESH
Adult
Humans
Kinetics
Male
Methyltyrosines
Thyroxine
Triiodothyronine
Tyrosine 3-Monooxygenase
alpha-Methyltyrosine
Abstract
To determine if the adrenergic nervous system, and specifically tyrosine hydroxylase, plays a role in the extrathyroidal conversion of T4 to T3, normal male volunteers were treated with T4 and subsequently with T4 and alpha-methyl-p-tyrosine (alpha-MPT), an inhibitor of tyrosine hydroxylase, for 2 weeks. The mean serum T4 and T3 concentrations increased during T4 administration and remained at the same levels during combined T4 and alpha-MPT administration. Urinary vanillylmandelic acid excretion declined significantly during alpha-MPT administration. These results do not support the hypothesis that tyrosine hydroxylase is involved in extrathyroidal T3 production.
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5.4
J Clin Endocrinol Metabjournal of clinical endocrinology & metabolism
Metadata
LocationUnited States
FromENDOCRINE SOC

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