MedicGo
GH secretion in two siblings with Laron's dwarfism: the effects of glucose, arginine, somatostatin, and bromocryptine.
Metadata
Journaljournal of clinical endocrinology & metabolism5.399Date
1978-Aug
Type
Journal Article
Case Report
Volume
1978-Aug / 47 : 453-6
Author
Alcañiz JJ , Salto L , Barcelo B
DoiPMIDMESH
Adult
Arginine
Bromocriptine
Child
Dwarfism
Female
Glucose
Growth Hormone
Humans
Kinetics
Male
Somatostatin
Syndrome
Thyroxine
Triiodothyronine
Abstract
The secretion of GH in two siblings with clinical dwarfism and high GH plasma levels (the mean of several basal values; 233.83 ng/ml in patient A and 178.16 in patient B has been studied with several dynamic tests. An arginine infusion increased GH levels in both cases (+193.55% for A, +140.27% for B). No significant modifications were obtained with oral glucose tolerance test +18.70% for A, +24.32% for B). A bolus of somatostatin almost completely prevented the rise in GH levels in response to arginine. Pretreatment with bromocryptine clearly increased basal GH plasma levels (A, +58.66%; B, +56.03%) and the response to arginine. As in the case of a normal hypothalamus, the hypothalamus of Laron's syndrome responds to arginine and bromocryptine, with GH elevations. Somatostatin suppresses GH levels. A lack of response to glucose can be considered as a nonspecific effect of the very low biological activity of the stimulus in a hyperstimulated hypothalamus. We suggest that GH secretion by the hypothalmo pituitary system in Laron's syndrome is normal, and that GH hyperproduction may be due to a generalized defect in GH receptors or to the low levels of somatomedin.
Fav
Like
Download
Share
Export
Cite
5.4
J Clin Endocrinol Metabjournal of clinical endocrinology & metabolism
Metadata
LocationUnited States
FromENDOCRINE SOC

No Data

© 2017 - 2020 Medicgo
Powered by some medical students