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Inhibitory effect of guanfacine, a central alpha-adrenoceptor agonist, on prolactin secretion stimulated by insulin-induced hypoglycemia.
Metadata
Journaljournal of clinical endocrinology & metabolism5.399Date
1978-Sep
Type
Journal Article
Volume
1978-Sep / 47 : 671-4
Author
Lancranjan I , del Pozo E , Ohnhaus E
DoiPMIDMESH
Adrenergic alpha-Agonists
Adult
Guanfacine
Guanidines
Humans
Hypoglycemia
Insulin
Kinetics
Male
Metoclopramide
Phenylacetates
Prolactin
Abstract
In six normal male volunteers oral administration of an alpha-receptor agonist, guanfacine (1 mg/q.i.d. for 4 days), had no effect on PRL release induced by 5 mg metoclopramide iv. The same treatment with quanfacine in six other normal subjects significantly reduced PRL secretion stimulated by insulin-induced hypoglycemia (P less than 0.05). These results suggest that an adrenergic pathway, hypothalamic or extrahypothalamic, might be involved in the inhibitory control of PRL secretion.
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5.4
J Clin Endocrinol Metabjournal of clinical endocrinology & metabolism
Metadata
LocationUnited States
FromENDOCRINE SOC

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