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Somatostatin inhibits thyroid hormone secretion induced by exogenous TSH in man.
Metadata
Journaljournal of clinical endocrinology & metabolism5.399Date
1978-Nov
Type
Journal Article
Volume
1978-Nov / 47 : 1156-9
Author
Ahrén B , Ericsson M , Hedner P , Ingemansson S , Westgren U
DoiPMIDMESH
Adult
Aged
Female
Humans
Male
Middle Aged
Somatostatin
Thyroid Gland
Thyroid Hormones
Thyrotropin
Thyroxine
Triiodothyronine
Triiodothyronine, Reverse
Veins
Abstract
The effect of somatostatin on thyroid hormone secretion stimulated by TSH in man was studied. The injection of TSH into a thyroid artery during surgery was followed by an increase in the serum concentration of iodothyronines in the corresponding thyroid vein. This increase was significantly lower (p less than 0.02) when somatostatin was given as a bolus injection into a peripheral vein 5 min prior to the administration of TSH, and followed by a continuous infusion for 60 min. Since somatostatin-like immunoreactivity has been localized to some cells of the thyroid gland being in a parafollicular location, it is suggested that somatostatin may be an intrathyroidal regulator of thyroid activity in man.
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5.4
J Clin Endocrinol Metabjournal of clinical endocrinology & metabolism
Metadata
LocationUnited States
FromENDOCRINE SOC

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