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Creatine phosphokinase isoenzymes and Trypanosoma cruzi infections.
Metadata
JournalComp. Biochem. Physiol., BNot FoundDate
1979
Type
Journal Article
Volume
1979 / 64 : 11-5
Author
Mercado TI 1, Garbus J
Affiliation

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Doi
PMIDMESH
Animals
Chagas Disease
Creatine Kinase
Electrophoresis, Disc
Isoenzymes
Male
Mice
Muscles
Myocardium
Trypanosoma cruzi
gamma-Glutamyltransferase
Abstract
1. Substantial increases in total creatine phosphokinase (CPK) and in isoenzymes from heart (CPK-MB) and skeletal muscle (CPK-MM) were observed during acute infections with the House 510 and House 11 strains of Trypanosoma cruzi. 2. In infections with the reticulotropic Tulahuen strain total CPK levels were lower and the isoenzyme pattern was essentially normal. 3. Gamma-glutamyl transpeptidase was considerably increased in the Tulahuen but not in the House 510 and House 11 infections. 4. These findings are useful in assessing tissue damage during T. cruzi infections and they also demonstrate differences between myotropic and reticulotropic strains which may aid in their taxonomic classification.
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Comp. Biochem. Physiol., BComparative biochemistry and physiology. B, Comparative biochemistry
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