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Effects of 2,4-dinitrophenol on trichomonads and Entamoeba invadens.
Metadata
JournalComp. Biochem. Physiol., BNot FoundDate
1979
Type
Research Support, U.S. Gov't, P.H.S.
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Journal Article
Volume
1979 / 64 : 97-100
Author
Müller M 1, Nseka V , Mack SR , Lindmark DG
Affiliation

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Doi
PMIDMESH
2,4-Dinitrophenol
Anaerobiosis
Animals
Color
Dinitrophenols
Entamoeba
Gases
Hydrogen-Ion Concentration
Metronidazole
Trichomonas
Trichomonas vaginalis
Abstract
1. 2,4-Dinitrophenol (2,4-DNP) in substrate level concentrations (200 microM-1 mM) temporarily inhibits H2 production by Tritrichomonas foetus and Trichomonas vaginalis as well as the accumulation of metronidazole, dependent on its reduction by the two trichomonad species and by Entamoeba invadens. 2. 2,4-DNP competes for the reducing equivalents which are necessary for H2 production or for the reduction of metronidazole, thereby inhibiting these processes. 2,4-DNP is reduced to 2-amino, 4-nitrophenol. 3. 2,4-DNP in concentrations up to 800 microM has no effect on the uptake of O2 by these organisms. 4. 2,4-DNP has some toxicity for T. foetus.
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Comp. Biochem. Physiol., BComparative biochemistry and physiology. B, Comparative biochemistry
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