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A schizophreniform behavioral psychosis mediated by dopamine.
Metadata
Journalamerican journal of psychiatry14.119Date
1975-Jan
Type
Journal Article
Volume
1975-Jan / 132 : 33-8
Author
Garver DL 1, Schlemmer RF , Maas JW , Davis JM
Affiliation

No Data

Doi
PMIDMESH
Animals
Antipsychotic Agents
Dextroamphetamine
Disease Models, Animal
Macaca
Receptors, Dopamine
Schizophrenia
Abstract
The authors conducted a study in which schizophrenic-like behavioral disturbances were induced in members of a macaque social colony by the chronic administration of d-amphetamine. Animals given the drug showed hypervigilance, hyperactivity, fragmented and repetitive behaviors, and progressive social withdrawal as well as the development of solitary stereotypies. The syndrome was dissected pharmacologically with alpha-methyl-para-tyrosine, chlorpromazine, pimozide, and haloperidol. Based on the behavioral findings and the known mechanisms of action of these drugs, the authors conclude that the major elements of the psychotic-like behavior induced by d-amphetamine were mediated by dopamine systems.
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14.1
Am J Psychiatryamerican journal of psychiatry
Metadata
LocationUnited States
FromAMER PSYCHIATRIC PUBLISHING, INC

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