MedicGo
[Effect of antianginal drugs on the exertion electrocardiogram].
Metadata
JournalArch Inst Cardiol MexNot FoundDate
1976-May-Jun
Type
Journal Article
English Abstract
Trial
Trial
Volume
1976-May-Jun / 46 : 317-24
Author
Moragrega Adame JL 1, Peña Vincent H
Affiliation

No Data

Doi
Not Found
PMIDMESH
Adrenergic beta-Antagonists
Angina Pectoris
Electrocardiography
Exercise Test
Female
Humans
Male
Middle Aged
Nitroglycerin
Oxygen Consumption
Penbutolol
Physical Exertion
Propranolol
Random Allocation
Abstract
In order to evaluate the clinical efficacy on penbutolol (Hoe 893 d), a new adrenergic blocking agent, two groups of 10 patients (A & B) with ischemic heart disease were chosen. These were submitted to exercise testing for 3 minutes, and placebos, nitroglycerin, and propranolol were used as reference preparations. As an index of indirect consumption of oxygen we determined the maximum cardiac frequency (MCF), maximum systolic arterial pressure (MAP) and the maximum double product (MDP). An electrocardiographic control of the patients was also included to observe ST segment changes. The patients from group A received 0.8 mg. of nitroglycerin sublingual as the first treatment and 40 mg. of propranolol as the second. The patients from group B received initially a placebo P.O. and then 25 mg. of penbutolol P.O. In both groups the exercise testing was repeated 10 minutes after the administration of the first substance and 10 minutes after the second. The results showed that 25 mg. of penbutolol and 40 mg. of propranolol have similar therapeutic effects over the degree, intensity, and duration of the differences in elevation of the ST segment, MCF, MAP, and MDP when you compare the results of their own controls with those obtained with the active principle. There is no significant difference observed in the results obtained in each parameter studied between penbutolol and propranolol. During the period of this clinical study there were no undesirable collateral effects caused by the oral administration of the investigated drugs.
Fav
Like
Download
Share
Export
Cite
A
Arch Inst Cardiol MexArchivos del Instituto de Cardiologia de Mexico
Metadata
Location
From

No Data

© 2017 - 2020 Medicgo
Powered by some medical students