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Methotrexate nephrotoxicity.
Metadata
JournalClin Exp Pharmacol Physiol SupplNot FoundDate
1979
Type
Journal Article
Volume
1979 / 5 : 43-5
Author
Fox RM 1
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Not Found
PMIDMESH
Chemical Phenomena
Chemistry
Humans
Hydrogen-Ion Concentration
Kidney
Methotrexate
Solubility
Abstract
The use of high dose methotrexate therapy in the treatment of malignant disease has been complicated by nephrotoxicity. Analysis of the basic physico-chemical properties of methotrexate has allowed the development of improved techniques of administering methotrexate, at high dose, which greatly reduces the incidence of nephrotoxicity.
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Clin Exp Pharmacol Physiol SupplClinical and experimental pharmacology & physiology. Supplement
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