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Short and long-term effects of neuroleptics in relation to their cellular mechanism of action.
Metadata
JournalProg NeuropsychopharmacolNot FoundDate
1979
Type
Review
Research Support, U.S. Gov't, P.H.S.
Research Support, Non-U.S. Gov't
Journal Article
Volume
1979 / 3 : 259-69
Author
Stefanis CN 1, Issidorides MR
Affiliation

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Doi
PMIDMESH
Antipsychotic Agents
Cell Nucleus
Chromatin
Dopamine
Humans
Liver
Neuroglia
Neurotransmitter Agents
Neutrophils
Subcellular Fractions
Synapses
Abstract
1. Some mechanisms of action of neuroleptics at cellular level are reviewed, mainly the effects on synaptic transmission and the effects on chromatin. 2. As regard to the effects at synaptic level, a brief review is presented on the available evidence in support of the currently prevailing dopamine hypothesis. 3. Studies carried out on the mechanisms and sites of action of neuroleptics on chromatin show that: a. Behavioral changes caused by psychotropic drugs in experimental animals are associated with chromatin alterations and induced macromolecular syntheses. b. Parkinsonian and possibly drug-induced extrapyramidal symptoms are associated with aberrations in protein synthesis. c. Destabilization under "stress" of the heterochromatin in schizophrenics seems to be due to histone modifications and is partly prevented by neuroleptic treatment.
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Prog NeuropsychopharmacolProgress in neuro-psychopharmacology
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