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Treatment of schizophrenia.
Metadata
JournalProg NeuropsychopharmacolNot FoundDate
1979
Type
Review
Journal Article
Volume
1979 / 3 : 47-52
Author
Beckmann B 1, Hippius H , Rüther E
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Doi
PMIDMESH
Antipsychotic Agents
Biogenic Monoamines
Humans
Schizophrenia
Abstract
1. Progress in 25 years' history of the neuroleptics is briefly reviewed. 2. Development of certain butyrophenones more directly effective in "minus" symptoms of schizophrenia and introduction of depot neuroleptics is discussed. 3. Extrapyramidal motor side effects (EPMS) are still a serious problem in the treatment. 4. Clozapine does not have EPMS. This drug could therefore become the starting point of a series of less hazardous antipsychotic drugs. 5. The neuroleptics can be used as tools for exploration of the etiopathogenesis of schizophrenia. Some important pharmacological mechanisms, i.e. their antidopaminergic activity, are briefly outlined.
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Prog NeuropsychopharmacolProgress in neuro-psychopharmacology
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