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Is a dopaminergic system involved in thyrotropin releasing hormone induced hyperthermia and in its potentiation by amphetamine?
Metadata
JournalProg NeuropsychopharmacolNot FoundDate
1979
Type
Research Support, Non-U.S. Gov't
Journal Article
Volume
1979 / 3 : 337-44
Author
Rips R 1, Desiles M , Puech AJ
Affiliation

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Doi
PMIDMESH
Amphetamine
Animals
Apomorphine
Chlorpromazine
Dopamine
Dopamine Agents
Female
Fever
Haloperidol
Levodopa
Methyltyrosines
Mice
Neurotransmitter Agents
Pimozide
Thyrotropin-Releasing Hormone
alpha-Methyltyrosine
p-Chloroamphetamine
Abstract
1. A dose-related hyperthermia is obtained in mice with TRH administered intraperitoneally. 2. This hyperthermia is reinforced by amphetamine given at doses which usually cause hypothermia. 3. p-Chloroamphetamine and L-Dopa also reinforce TRH hyperthermia. Apomorphine is not significantly active. 4. TRH hyperthermia is lowered significantly by alpha-methyl-tyrosine and haloperidol but not significantly by pimozide and chlorpromazine. TRH + Amph hyperthermia is not lowered by any of the DA antagonists tested even at doses reversing Amph hyperthermia. Direct participation of DA receptors is then doubtful. 5. All these variations of temperature have their acme a 15 min except for reserpine which, given 22 hours before, potentiates TRH + Amph hyperthermia after 30 min.
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Prog NeuropsychopharmacolProgress in neuro-psychopharmacology
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