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Enkephalin-dopamine interactions in behavioral arousal.
Metadata
JournalProg NeuropsychopharmacolNot FoundDate
1979
Type
Research Support, U.S. Gov't, P.H.S.
Journal Article
Comparative Study
Volume
1979 / 3 : 395-8
Author
Katz RJ 1, Carroll BJ
Affiliation

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Doi
PMIDMESH
Animals
Behavior, Animal
Catecholamines
Dopamine Agents
Dopamine Antagonists
Enkephalins
Fluspirilene
Imidazolines
Male
Mice
Pimozide
Receptors, Dopamine
Abstract
1. Central injection of a long lasting enkephalin analog (D-Ala2-leu-enkephalin-amide) produced a syndrome of stereotyped motor activity. 2. This activation syndrome was significantly reduced by two dopamine (DA) blockers (pimozide, fluspririlene) and by an agonist of inhibition-mediating DA receptors [(3,4-dihydroxyphenylamino)-2-imidazoline]. 3. Intact DA functioning is necessary for the occurrence of this enkephalin-mediated behavioral syndrome.
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Prog NeuropsychopharmacolProgress in neuro-psychopharmacology
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