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An intrarenal effect of somatostatin on water excretion.
Metadata
Journalendocrinology3.934Date
1977-Mar
Type
Research Support, U.S. Gov't, P.H.S.
Research Support, Non-U.S. Gov't
Journal Article
Volume
1977-Mar / 100 : 782-5
Author
Reid IA 1, Rose JC
Affiliation

No Data

Doi
PMIDMESH
Animals
Cyclic AMP
Diuresis
Dogs
Kidney
Regional Blood Flow
Somatostatin
Water-Electrolyte Balance
Abstract
Intrarenal infusion of somatostatin in anesthetized dogs produced a prompt increase in urine flow in association with a decrease in urinary osmolality and an increase in free water clearance. These changes occurred in the absence of changes in arterial pressure, renal plasma flow, osmolar clearance, electrolyte excretion or cyclic AMP excretion. The diuretic effect occurred primarily in the infused kidney indicating a direct intrarenal action rather than suppression of vasopressin secretion. This diuretic action of somatostatin may result from inhibition of the action of vasopressin on the renal medulla but other possible mechanisms cannot be excluded.
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3.9
Endocrinologyendocrinology
Metadata
LocationUnited States
FromENDOCRINE SOC

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