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Selective viral immunosuppression of the graft-versus-host reaction.
Metadata
Journaljournal of experimental medicine11.743Date
1977-Mar-01
Type
Research Support, U.S. Gov't, P.H.S.
Journal Article
Volume
1977-Mar-01 / 145 : 666-75
Author
Romano TJ 1, Nowakowski M , Bloom BR , Thorbecke GJ
Affiliation

No Data

Doi
PMIDMESH
Animals
Graft vs Host Reaction
Immune Tolerance
Male
Mice
Mice, Inbred C57BL
T-Lymphocytes
Vesicular stomatitis Indiana virus
Abstract
Graft-vs.-host (GVH) reactivity of parental lymph node (LN) cells was assayed by measurements of 3H-thymidine incorporation in vivo in spleens of irradiated F1 recipients. Preincubation of parental LN cells with vesicular stomatitis virus (VSV) for 2 h at 37 degrees C followed by washing resulted in an 85-90% reduction in splenic radioactivity, as did injection of VSV on days 0-2 after recipients received untreated parental LN cells. In contrast, 3H-thymidine incorporation in the spleens or irradiated F1 hosts was not affected by VSV when F1 bone marrow cells were incubated with the virus. In addition, preincubation of F1 B cells with VSV still allowed these syngeneic B cells to be recruited into proliferation by mitomycin-treated parental LN cells. The inhibitory effect of VSV, thus, seems to be specific for T-cell proliferation. These observations suggest that viral immunosuppression might be capable of being developed into a useful strategy for selective deletion of lymphocytes capable of reacting against histocompatibility antigens and initiating GVH reactions.
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11.7
J Exp Medjournal of experimental medicine
Metadata
LocationUnited States
FromROCKEFELLER UNIV PRESS

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