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The susceptibility of Vero cell cultures for human adenoviruses.
Metadata
Journalmedical microbiology and immunology1.961Date
1978
Type
Research Support, Non-U.S. Gov't
Journal Article
Volume
1978 / 164 : 267-75
Author
Hasler P 1, Wigand R
Affiliation

No Data

Doi
PMIDMESH
Adenoviridae
Animals
Cells, Cultured
Cytopathogenic Effect, Viral
HeLa Cells
Humans
Microbiological Techniques
Simian virus 40
Vero Cells
Virus Cultivation
Abstract
Human adenoviruses 1 to 28 were shown to produce a cytopathic effect in Vero cell cultures. Viruses of subgroups III and IV (Ad 1, 2, 5, 6, 12, and 18) were readily passaged in Vero cell cultures and were produced in high amounts. This was also found for Ad 11, 16, and 21, while Ad 3, 4, and 7 showed a lower degree of multiplication and Ad 14 could not be passed serially. For Ad 8, 26, 27, 20, 25, and 28, a multiplication in Vero cells could not be proved, while the remaining serotypes of subgroup II showed a moderate degree of multiplication. The sensitivity of Vero cells to small amounts of virus was lower than that of HeLa cells. No adaption of adenoviruses to Vero cells after 5 Vero passages was observed. Attempts to enhance virus multiplication by coinfection with SV40 failed.
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Med Microbiol Immunolmedical microbiology and immunology
Metadata
LocationGermany
FromSPRINGER

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