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A/New Jersey/76 influenza vaccine trial in seronegative schoolchildren: comparison of a subunit vaccine with a whole-virus vaccine.
Metadata
Journalmedical microbiology and immunology1.961Date
1978
Type
RCT
Journal Article
Comparative Study
Trial
Volume
1978 / 164 : 277-84
Author
Just M 1, Bürgin-Wolff A , Berger-Hernandez R , Bächlin A , Ritzel G , Moritz AJ
Affiliation

No Data

Doi
PMIDMESH
Antibodies, Viral
Child
Double-Blind Method
Female
Humans
Immunization, Secondary
Influenza A virus
Influenza Vaccines
Influenza, Human
Injections, Intramuscular
Male
Vaccination
Vaccines, Synthetic
Abstract
In the present vaccination trial, 202 seronegative schoolchildren comprising both sexes and aged 11 to 12 years were vaccinated i.m. in the upper arm with either the subunit vaccine at a dosage of 600 CCA or 200 CCA or with a whole-virus vaccine at a dosage of 200 CCA, using the double-blind procedure. Both vaccines were prepared from the strain A/New Jersey/76 (x 53a-recombinant). The vaccination was followed four weeks later by a booster injection. In tests of local and systemic reactogenicity, it was found that at both dosages the subunit vaccine caused a low frequency of minor adverse reactions. The whole-virus vaccine was marked by a significantly higher rate of adverse reactions, whether of the local or systemic variety. The whole-virus vaccine had, however, a higher immunogenicity than the subunit vaccine, and due to the relatively high rate of adverse reactions it causes, it is not recommended for the vaccination of seronegative children. Because of its low reactogenicity, the subunit vaccine can be given at higher dosage, and it is a matter for consideration whether a better antibody response might not result from two booster injections.
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Med Microbiol Immunolmedical microbiology and immunology
Metadata
LocationGermany
FromSPRINGER

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