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The genetic fine structure of the complex locus aro3 involved in early aromatic amino acid biosynthesis in Schizosaccharomyces pombe.
Metadata
JournalMol. Gen. Genet.Not FoundDate
1979
Type
Research Support, Non-U.S. Gov't
Journal Article
Comparative Study
Volume
1979 / 172 : 233-41
Author
Strauss A 1
Affiliation

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Doi
PMIDMESH
Alleles
Amino Acids
Genes, Fungal
Genes, Suppressor
Genetic Complementation Test
Meiosis
Neurospora crassa
Recombination, Genetic
Schizosaccharomyces
Abstract
The complex locus aro3 of Schizosaccharomyces pombe was subjected to genetical fine structure analysis. By comparing the complementation map and the meiotic recombination map, the aro3 locus could be subdivided into the five adjacent subregions A, B, C, D and E. Out of 115 aro3 alleles, 26 nonsense alleles and 30 missense alleles could be identified by the criteria of nonsense suppressor sensitivity and leakiness, respectively. Most alleles with a pleiotropic complementation pattern are of the nonsense type. We conclude from the polarity of the complementation patterns characterising the nonsense alleles that the translation direction proceeds from subregion. A to subregion E. Antipolar effects in complementation are more frequent than in the analogous system of the arom gene cluster of Neurospora crassa.
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Mol. Gen. Genet.Molecular & general genetics : MGG
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