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Genetic control of maltase synthesis in yeast. IV. Function of the MAL4 gene: extragenic suppression of a maltase negative mutant.
Metadata
JournalMol. Gen. Genet.Not FoundDate
1979
Type
Journal Article
Volume
1979 / 172 : 281-5
Author
Khan NA 1
Affiliation

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Doi
PMIDMESH
Alleles
Crosses, Genetic
Fermentation
Fungal Proteins
Genes, Fungal
Saccharomyces cerevisiae
Suppression, Genetic
alpha-Glucosidases
Abstract
A new series of maltase negative mutants have been isolated from yeast strains carrying the MAL4 gene. These mutants are allelic to the MAL4 gene and fail to ferment maltose, sucrose, and alpha-methylglucoside. Most revertants isolated from these mutants restore the ability to ferment above sugars, and also produce the same levels of maltase as the parental strains. One of the revertants (NA-520-R1), however, ferments maltose slowly, and produces 24 fold less enzyme than the parental strain. Genetic studies revealed that revertant (NA-520-R1), is not a true back mutation but is carrying an extra-genic suppressor, which suppresses the mal4 allele in mutant (NA-520). Since several lines of published evidence indicate that the MAL4 gene is a regulatory gene, it is suggested that the MAL4 gene codes for a regulatory protein, which acts as a positive regulatory element in maltase synthesis.
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Mol. Gen. Genet.Molecular & general genetics : MGG
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