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Some physicochemical properties of hemoglobin-manitoba (alpha2 102Ser replaced by Arg (G9) beta2).
Metadata
JournalBiochim. Biophys. ActaNot FoundDate
1975-Dec-15
Publication Type
Research Support, U.S. Gov't, P.H.S.
Journal Article
Volume
1975-Dec-15 / 412 : 283-7
Author
Wrightstone RN , Smith LL , Wilson JB , Vella F , Huisman TH
DoiPMIDMESH
Adult
Arginine
Electrophoresis, Starch Gel
Female
Genetic Variation
Hemoglobins, Abnormal
Humans
Hydrogen-Ion Concentration
Male
Manitoba
Oxyhemoglobins
Serine
Temperature
Abstract
Hb-Manitoba was discovered in 1970 [1] in a Canadian family of British origin. Recently we observed the same variant in a second family, and found that the oxy-derivative of Hb-Manitoba is slightly unstable at 65 degrees C, dissociates less readily at alkaline pH than does Hb-A, and forms asymmetric hybrids with other hemoglobins which are readily detectable by electrophoresis.
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